Three additional CESG grants were funded from 2010-2015.
The Mitochondrial Protein Partnership (MPP) applied technologies developed by the PSI to problems of interest to the community of biologists and biochemists who investigate the role of mitochondria in human health and disease.
The goals of Natural Products Biosynthesis (NATPRO) are to apply technologies developed by the PSI to problems of interest to the community of biologists and biochemists who investigate the role of natural products in human health and disease.
The goal of the Transmembrane Protein Center (TMPC) was to apply technologies developed under the aegis of the PSI:Biology Network to problems of interest to the community of biologists and biochemists who investigate the role of membrane proteins in human health and disease.
The Center for Eukaryotic Structural Genomics (CESG) was a specialized research center supported by the Protein Structure Initiative (PSI) of the National Institute of General Medical Sciences (NIGMS), one of the National Institutes of Health (NIH) from 2001-2010.
PSI was a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure. The long-range goal of PSI was to solve 10,000 protein structures in 10 years and to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences.
CESG was housed within the Department of Biochemistry at the University of Wisconsin-Madison (Madison, WI) and also the Department of Biochemistry at the Medical College of Wisconsin (Milwaukee, WI). CESG developed new methods and technologies to address unique eukaryotic bottlenecks and disseminated its methodologies and experimental results to the scientific community worldwide through:
We have welcomed requests by researchers to solve eukaryotic protein structures, particularly medically relevant proteins, through our Online Structure Request System for Researchers. We have solved many community-nominated targets and deposited information about these targets in public databases and published on our investigations and findings.
All of CESG's experimental results, corresponding protocols, and publications were deposited into the following online repositories and databases:
CESG was supported by NIH / NIGMS Protein Structure Initiative grant numbers U54 GM074901 (JLM; 07/01/05 - 06/30/10) and P50 GM064598 (JLM; 01/01/02 - 08/31/05).